3E8L
The Crystal Structure of the Double-headed Arrowhead Protease Inhibitor A in Complex with Two Trypsins
Summary for 3E8L
Entry DOI | 10.2210/pdb3e8l/pdb |
Descriptor | Serine proteinase inhibitor A, Cationic trypsin, GLYCEROL, ... (10 entities in total) |
Functional Keywords | beta-trefoil fold, protease inhibitor, trypsin, complex, digestion, hydrolase, metal-binding, protease, secreted, serine protease, zymogen, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase |
Biological source | Sagittaria sagittifolia (Arrowhead) More |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 3 |
Total formula weight | 68656.12 |
Authors | Bao, R.,Jiang, C.-H.,Chi, C.W.,Lin, S.X.,Chen, Y.X. (deposition date: 2008-08-20, release date: 2009-07-28, Last modification date: 2023-11-01) |
Primary citation | Bao, R.,Zhou, C.Z.,Jiang, C.-H.,Lin, S.X.,Chi, C.W.,Chen, Y.X. The ternary structure of double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. J.Biol.Chem., 284:26676-26684, 2009 Cited by PubMed: 19640842DOI: 10.1074/jbc.M109.022095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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