3DUX
Understanding Thrombin Inhibition
Summary for 3DUX
Entry DOI | 10.2210/pdb3dux/pdb |
Related | 2ZC9 2ZDA 2ZFP 2ZGX 2ZI2 2ZNK |
Related PRD ID | PRD_000610 |
Descriptor | Thrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-1, ... (6 entities in total) |
Functional Keywords | blood clotting, hydrolase inhibitor, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
Total number of polymer chains | 3 |
Total formula weight | 35735.12 |
Authors | |
Primary citation | Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin J.Mol.Biol., 391:552-564, 2009 Cited by PubMed: 19520086DOI: 10.1016/j.jmb.2009.06.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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