3DTW

Crystal structure of the VEGFR2 kinase domain in complex with a benzisoxazole inhibitor

Summary for 3DTW

Entry DOI	10.2210/pdb3dtw/pdb
Descriptor	Vascular endothelial growth factor receptor 2, 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide (3 entities in total)
Functional Keywords	angiogenesis, receptor tyrosine kinase, transferase
Biological source	Homo sapiens (human) More
Cellular location	Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains	2
Total formula weight	73436.71
Authors	Whittington, D.A.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2008-07-16, release date: 2008-09-09, Last modification date: 2024-02-21)
Primary citation	Kunz, R.K.,Rumfelt, S.,Chen, N.,Zhang, D.,Tasker, A.S.,Burli, R.,Hungate, R.,Yu, V.,Nguyen, Y.,Whittington, D.A.,Meagher, K.L.,Plant, M.,Tudor, Y.,Schrag, M.,Xu, Y.,Ng, G.Y.,Hu, E. Discovery of amido-benzisoxazoles as potent c-Kit inhibitors. Bioorg.Med.Chem.Lett., 18:5115-5117, 2008 Cited by PubMed: 18723346 DOI: 10.1016/j.bmcl.2008.07.111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation