3DRP
HIV reverse transcriptase in complex with inhibitor R8e
Summary for 3DRP
Entry DOI | 10.2210/pdb3drp/pdb |
Related | 3DRR 3DRS |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, hydrolase, transferase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 117052.99 |
Authors | Yan, Y.,Prasad, S. (deposition date: 2008-07-11, release date: 2008-10-14, Last modification date: 2023-08-30) |
Primary citation | Tucker, T.J.,Sisko, J.T.,Tynebor, R.M.,Williams, T.M.,Felock, P.J.,Flynn, J.A.,Lai, M.T.,Liang, Y.,McGaughey, G.,Liu, M.,Miller, M.,Moyer, G.,Munshi, V.,Perlow-Poehnelt, R.,Prasad, S.,Reid, J.C.,Sanchez, R.,Torrent, M.,Vacca, J.P.,Wan, B.L.,Yan, Y. Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses. J.Med.Chem., 51:6503-6511, 2008 Cited by PubMed: 18826204DOI: 10.1021/jm800856c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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