3DPD

Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-Dihydro-2H-benzo[1,4]oxazines

Summary for 3DPD

Entry DOI	10.2210/pdb3dpd/pdb
Related	1e8y
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one (2 entities in total)
Functional Keywords	phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k, kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	111022.52
Authors	Ceska, T.A. (deposition date: 2008-07-08, release date: 2008-08-26, Last modification date: 2023-11-01)
Primary citation	Perry, B.,Alexander, R.,Bennett, G.,Buckley, G.,Ceska, T.,Crabbe, T.,Dale, V.,Gowers, L.,Horsley, H.,James, L.,Jenkins, K.,Crepy, K.,Kulisa, C.,Lightfoot, H.,Lock, C.,Mack, S.,Morgan, T.,Nicolas, A.-L.,Pitt, W.,Sabin, V.,Wright, S. Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines Bioorg.Med.Chem.Lett., 18:4700-4704, 2008 Cited by PubMed: 18644721 DOI: 10.1016/j.bmcl.2008.06.104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation