3DJF

Crystal Structure of Schistosoma mansoni Purine Nucleoside Phosphorylase in a complex with BCX-34

Summary for 3DJF

Entry DOI	10.2210/pdb3djf/pdb
Related	1tcu 1tcv 1td1
Descriptor	Purine-nucleoside phosphorylase, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	purine nucleoside phosphorylase, bcx34, inhibitor, glycosyltransferase, transferase
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	3
Total formula weight	94742.03
Authors	Postigo, M.P.,Pereira, H.M.,Oliva, G.,Andricopulo, A.D. (deposition date: 2008-06-23, release date: 2009-06-30, Last modification date: 2024-02-21)
Primary citation	Castilho, M.S.,Postigo, M.P.,Pereira, H.M.,Oliva, G.,Andricopulo, A.D. Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: kinetic and structural studies. Bioorg.Med.Chem., 18:1421-1427, 2010 Cited by PubMed: 20129792 DOI: 10.1016/j.bmc.2010.01.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.302 Å)

Structure validation