3DCU
FXR with SRC1 and GSK8062
Summary for 3DCU
Entry DOI | 10.2210/pdb3dcu/pdb |
Related | 3DCT |
Descriptor | Bile acid receptor, Nuclear receptor coactivator 1, 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)naphthalene-1-carboxylic acid, ... (4 entities in total) |
Functional Keywords | fxr, nuclear receptor, gw4064, alpha-helical sandwich, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, transcription-transcription activator complex, transcription/transcription activator |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1 Nucleus : Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 30692.03 |
Authors | Williams, S.P.,Madauss, K.P. (deposition date: 2008-06-04, release date: 2008-08-12, Last modification date: 2023-08-30) |
Primary citation | Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Jones, S.A.,Kaldor, I.,Liu, Y.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,III, F.N.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B. Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg.Med.Chem.Lett., 18:4339-4343, 2008 Cited by PubMed: 18621523DOI: 10.1016/j.bmcl.2008.06.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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