3DBE
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 557
Summary for 3DBE
Entry DOI | 10.2210/pdb3dbe/pdb |
Related | 3d5w 3db6 3db8 3dbc 3dbd 3dbf |
Descriptor | Polo-like kinase 1, 3'-chloro-5'-[6-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-3-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]biphenyl-2-carboxamide (2 entities in total) |
Functional Keywords | polo-like kinase 1, plk1, catalytic domain, small-molecule inhibitor, kinase, transferase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 1 |
Total formula weight | 35066.24 |
Authors | Elling, R.A.,Barr, K.J.,Romanowski, M.J. (deposition date: 2008-05-31, release date: 2008-10-07, Last modification date: 2023-08-30) |
Primary citation | Fucini, R.V.,Hanan, E.J.,Romanowski, M.J.,Elling, R.A.,Lew, W.,Barr, K.J.,Zhu, J.,Yoburn, J.C.,Liu, Y.,Fahr, B.T.,Fan, J.,Lu, Y.,Pham, P.,Choong, I.C.,VanderPorten, E.C.,Bui, M.,Purkey, H.E.,Evanchik, M.J.,Yang, W. Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg.Med.Chem.Lett., 18:5648-5652, 2008 Cited by PubMed: 18793847DOI: 10.1016/j.bmcl.2008.08.095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.32 Å) |
Structure validation
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