3DA9

Crystal structure of thrombin in complex with inhibitor

Summary for 3DA9

Entry DOI	10.2210/pdb3da9/pdb
Descriptor	Thrombin light chain, Thrombin heavy chain, Hirudin peptide, ... (6 entities in total)
Functional Keywords	thrombin, inhibitor complex, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, serine protease, zymogen
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734
Total number of polymer chains	3
Total formula weight	35457.33
Authors	Xue, Y.,Hansson, S.K. (deposition date: 2008-05-29, release date: 2009-05-19, Last modification date: 2024-04-03)
Primary citation	Nilsson, M.,Hamalainen, M.,Ivarsson, M.,Gottfries, J.,Xue, Y.,Hansson, S.,Isaksson, R.,Fex, T. Compounds binding to the S2-S3 pockets of thrombin. J.Med.Chem., 52:2708-2715, 2009 Cited by PubMed: 19371038 DOI: 10.1021/jm8011849 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation