3D90
Crystal structure of the human progesterone receptor ligand-binding domain bound to levonorgestrel
Summary for 3D90
| Entry DOI | 10.2210/pdb3d90/pdb |
| Descriptor | Progesterone receptor, 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE (3 entities in total) |
| Functional Keywords | progesterone receptor, steroid receptor, nuclear receptor, transcription factor, women health, contraception, alternative splicing, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, steroid-binding, transcription, transcription regulation, zinc, zinc-finger |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus. Isoform A: Nucleus: P06401 |
| Total number of polymer chains | 2 |
| Total formula weight | 60102.54 |
| Authors | Petit-Topin, I.,Turque, N.,Ulman, A.,Gainer, E.,Rafestin-Oblin, M.E.,Fagart, J. (deposition date: 2008-05-26, release date: 2009-05-26, Last modification date: 2023-11-01) |
| Primary citation | Petit-Topin, I.,Turque, N.,Fagart, J.,Fay, M.,Ulmann, A.,Gainer, E.,Rafestin-Oblin, M.E. Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins Mol.Pharmacol., 75:1317-1324, 2009 Cited by PubMed: 19289570DOI: 10.1124/mol.108.054312 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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