3D7Z

Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor

Summary for 3D7Z

Entry DOI	10.2210/pdb3d7z/pdb
Related	2ZB0 2ZB1 3D83
Descriptor	Mitogen-activated protein kinase 14, SULFATE ION, N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide, ... (5 entities in total)
Functional Keywords	p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41895.79
Authors	Somers, D.O.,Patel, S. (deposition date: 2008-05-22, release date: 2008-07-22, Last modification date: 2023-11-15)
Primary citation	Angell, R.,Aston, N.M.,Bamborough, P.,Buckton, J.B.,Cockerill, S.,deBoeck, S.J.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Laine, D.I.,Patel, S.,Smee, P.A.,Smith, K.J.,Somers, D.O.,Walker, A.L. Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg.Med.Chem.Lett., 18:4428-4432, 2008 Cited by PubMed: 18614366 DOI: 10.1016/j.bmcl.2008.06.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation