3CZD
Crystal structure of human glutaminase in complex with L-glutamate
Summary for 3CZD
Entry DOI | 10.2210/pdb3czd/pdb |
Descriptor | Glutaminase kidney isoform, SULFATE ION, GLUTAMIC ACID, ... (5 entities in total) |
Functional Keywords | glutamine, glutamate, kidney isoform, k-glutaminase, sgc, structural genomics consortium, ank repeat, hydrolase, mitochondrion, transit peptide |
Biological source | Homo sapiens |
Cellular location | Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925 |
Total number of polymer chains | 1 |
Total formula weight | 35115.99 |
Authors | Karlberg, T.,Welin, M.,Andersson, J.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Lehtio, L.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wikstrom, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2008-04-29, release date: 2008-07-01, Last modification date: 2023-08-30) |
Primary citation | Thangavelu, K.,Pan, C.Q.,Karlberg, T.,Balaji, G.,Uttamchandani, M.,Suresh, V.,Schuler, H.,Low, B.C.,Sivaraman, J. Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109:7705-7710, 2012 Cited by PubMed: 22538822DOI: 10.1073/pnas.1116573109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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