3CU0

human beta 1,3-glucuronyltransferase I (GlcAT-I) in complex with UDP and GAL-GAL(6-SO4)-XYL(2-PO4)-O-SER

Summary for 3CU0

• Entry DOI: 10.2210/pdb3cu0/pdb
• Related: 1FGG 1KWS
• Descriptor: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, beta-D-galactopyranose-(1-3)-beta-D-galactopyranose, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: glcat-i, glycosyltransferase, heparan sulfate biosynthesis, glycoprotein, golgi apparatus, manganese, membrane, metal-binding, signal-anchor, transmembrane, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Golgi apparatus membrane; Single-pass type II membrane protein: O94766
• Total number of polymer chains: 2
• Total formula weight: 64121.78

Authors

Tone, Y.,Pedersen, L.C.,Yamamoto, T.,Kitagawa, H.,Nishihara-Shimizu, J.,Tamura, J.,Negishi, M.,Sugahara, K. (deposition date: 2008-04-15, release date: 2008-05-06, Last modification date: 2023-08-30)

• Primary citation: Tone, Y.,Pedersen, L.C.,Yamamoto, T.,Izumikawa, T.,Kitagawa, H.,Nishihara, J.,Tamura, J.,Negishi, M.,Sugahara, K.; 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis.; J.Biol.Chem., 283:16801-16807, 2008; PubMed: 18400750; DOI: 10.1074/jbc.M709556200

Experimental method

X-RAY DIFFRACTION (1.9 Å)