3CS9

Human ABL kinase in complex with nilotinib

Summary for 3CS9

Entry DOI	10.2210/pdb3cs9/pdb
Related	2HYY
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, Nilotinib (3 entities in total)
Functional Keywords	nilotinib, amn107, kinase, abl, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, abl kinase wt in complex with nvp-amn107
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	4
Total formula weight	130320.80
Authors	Cowan-Jacob, S.W.,Fendrich, G.,Manley, P.,Liebetanz, J.,Fabbro, D. (deposition date: 2008-04-09, release date: 2008-04-22, Last modification date: 2024-04-03)
Primary citation	Weisberg, E.,Manley, P.W.,Breitenstein, W.,Brueggen, J.,Cowan-Jacob, S.W.,Ray, A.,Huntly, B.,Fabbro, D.,Fendrich, G.,Hall-Meyers, E.,Kung, A.L.,Mestan, J.,Daley, G.Q.,Callahan, L.,Catley, L.,Cavazza, C.,Azam, M.,Neuberg, D.,Wright, R.D.,Gilliland, D.G.,Griffin, J.D. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl Cancer Cell, 7:129-141, 2005 Cited by PubMed: 15710326 DOI: 10.1016/j.ccr.2005.01.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation