3CLZ

The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA

Summary for 3CLZ

• Entry DOI: 10.2210/pdb3clz/pdb
• Related: 2FAZ 3BI7
• Descriptor: E3 ubiquitin-protein ligase UHRF1, 5'-D(*DGP*DGP*DGP*DCP*DCP*(5CM)P*DGP*DCP*DAP*DGP*DGP*DG)-3', 5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DGP*DGP*DCP*DCP*DC)-3', ... (4 entities in total)
• Functional Keywords: cell cycle, dna damage, dna repair, dna-binding, base flipping, ligase, metal binding, nuclease, dna replication, transcriptional silencing, chromatin, phosphorylation, transcription, transcription regulation, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger, structural genomics consortium, sgc, metal-binding, nucleus, phosphoprotein, polymorphism
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q96T88
• Total number of polymer chains: 12
• Total formula weight: 124453.33

Authors

Walker, J.R.,Avvakumov, G.V.,Xue, S.,Dong, A.,Li, Y.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-03-20, release date: 2008-04-29, Last modification date: 2023-08-30)

• Primary citation: Avvakumov, G.V.,Walker, J.R.,Xue, S.,Li, Y.,Duan, S.,Bronner, C.,Arrowsmith, C.H.,Dhe-Paganon, S.; Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.; Nature, 455:822-825, 2008; PubMed: 18772889; DOI: 10.1038/nature07273

Experimental method

X-RAY DIFFRACTION (2.2 Å)