3BI7
Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1
Summary for 3BI7
Entry DOI | 10.2210/pdb3bi7/pdb |
Related | 2FAZ |
Descriptor | E3 ubiquitin-protein ligase UHRF1, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | cell cycle, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphorylation, polymorphism, transcription, transcription regulation, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger, structural genomics consortium, sgc, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q96T88 |
Total number of polymer chains | 1 |
Total formula weight | 24254.58 |
Authors | Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-11-30, release date: 2007-12-18, Last modification date: 2011-07-13) |
Primary citation | Avvakumov, G.V.,Walker, J.R.,Xue, S.,Li, Y.,Duan, S.,Bronner, C.,Arrowsmith, C.H.,Dhe-Paganon, S. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature, 455:822-826, 2008 Cited by PubMed: 18772889DOI: 10.1038/nature07273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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