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3CDP

Crystal structure of PPAR-gamma LBD complexed with a partial agonist, analogue of clofibric acid

Summary for 3CDP
Entry DOI10.2210/pdb3cdp/pdb
Related1K74 3CDS
DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid (3 entities in total)
Functional Keywordsbundle of alpha-helices and a small four-stranded beta-sheet, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight65338.02
Authors
Pochetti, G.,Montanari, R.,Mazza, F. (deposition date: 2008-02-27, release date: 2009-01-13, Last modification date: 2024-03-13)
Primary citationFracchiolla, G.,Laghezza, A.,Piemontese, L.,Parente, M.,Lavecchia, A.,Pochetti, G.,Montanari, R.,Di Giovanni, C.,Carbonara, G.,Tortorella, P.,Novellino, E.,Loiodice, F.
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists
Bioorg.Med.Chem., 20:2141-2151, 2012
Cited by
PubMed: 22341573
DOI: 10.1016/j.bmc.2012.01.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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