3CDS

Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue)

Summary for 3CDS

Entry DOI	10.2210/pdb3cds/pdb
Related	1K74 3CDP
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid (3 entities in total)
Functional Keywords	bundle of alpha-helices and a small four-stranded beta-sheet, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65331.63
Authors	Pochetti, G.,Montanari, R.,Mazza, F. (deposition date: 2008-02-27, release date: 2008-12-30, Last modification date: 2024-03-13)
Primary citation	Montanari, R.,Saccoccia, F.,Scotti, E.,Crestani, M.,Godio, C.,Gilardi, F.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Tortorella, P.,Lavecchia, A.,Novellino, E.,Mazza, F.,Aschi, M.,Pochetti, G. Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design J.Med.Chem., 51:7768-7776, 2008 Cited by PubMed: 19053776 DOI: 10.1021/jm800733h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation