3CD3
Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide
Summary for 3CD3
Entry DOI | 10.2210/pdb3cd3/pdb |
Related | 3CBL |
Descriptor | Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | fes, v-fes, fujinami, avian sarcoma, viral, oncogene, feline sarcoma virus, active, sgc, structural genomics consortium, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 44958.26 |
Authors | Filippakopoulos, P.,Salah, E.,Cooper, C.,Picaud, S.S.,Elkins, J.M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-02-26, release date: 2008-03-25, Last modification date: 2023-11-15) |
Primary citation | Filippakopoulos, P.,Kofler, M.,Hantschel, O.,Gish, G.D.,Grebien, F.,Salah, E.,Neudecker, P.,Kay, L.E.,Turk, B.E.,Superti-Furga, G.,Pawson, T.,Knapp, S. Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation Cell(Cambridge,Mass.), 134:793-803, 2008 Cited by PubMed: 18775312DOI: 10.1016/j.cell.2008.07.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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