3C7Q
Structure of VEGFR2 kinase domain in complex with BIBF1120
Summary for 3C7Q
Entry DOI | 10.2210/pdb3c7q/pdb |
Descriptor | Vascular endothelial growth factor receptor 2, SULFATE ION, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, ... (4 entities in total) |
Functional Keywords | alpha beta, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 37576.93 |
Authors | Hilberg, F.,Roth, G.J.,Krssak, M.,Kautschitsch, S.,Sommergruber, W.,Tontsch-Grunt, U.,Garin-Chesa, P.,Bader, G.,Zoephel, A.,Quant, J.,Heckel, A.,Rettig, W.J. (deposition date: 2008-02-08, release date: 2008-12-23, Last modification date: 2023-11-15) |
Primary citation | Hilberg, F.,Roth, G.J.,Krssak, M.,Kautschitsch, S.,Sommergruber, W.,Tontsch-Grunt, U.,Garin-Chesa, P.,Bader, G.,Zoephel, A.,Quant, J.,Heckel, A.,Rettig, W.J. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res., 68:4774-4782, 2008 Cited by PubMed: 18559524DOI: 10.1158/0008-5472.CAN-07-6307 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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