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3C0Y

Crystal structure of catalytic domain of human histone deacetylase HDAC7

Replaces:  2NVRReplaces:  2I4Y
Summary for 3C0Y
Entry DOI10.2210/pdb3c0y/pdb
Related2NVR 3C0Z 3C10
DescriptorHistone deacetylase 7a, ZINC ION, POTASSIUM ION, ... (4 entities in total)
Functional Keywordshistone deacetylase, structural genomics, structural genomics consortium, sgc, alternative splicing, chromatin regulator, cytoplasm, hydrolase, nucleus, phosphoprotein, polymorphism, repressor, transcription, transcription regulation
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q8WUI4
Total number of polymer chains3
Total formula weight137182.06
Authors
Primary citationSchuetz, A.,Min, J.,Allali-Hassani, A.,Schapira, M.,Shuen, M.,Loppnau, P.,Mazitschek, R.,Kwiatkowski, N.P.,Lewis, T.A.,Maglathin, R.L.,McLean, T.H.,Bochkarev, A.,Plotnikov, A.N.,Vedadi, M.,Arrowsmith, C.H.
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283:11355-11363, 2008
Cited by
PubMed: 18285338
DOI: 10.1074/jbc.M707362200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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