3BZ3

Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor

Summary for 3BZ3

• Entry DOI: 10.2210/pdb3bz3/pdb
• Descriptor: Focal adhesion kinase 1, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide (3 entities in total)
• Functional Keywords: kinase, dfg-helix, acetylation, alternative splicing, atp-binding, cell junction, nucleotide-binding, phosphoprotein, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction, focal adhesion: Q05397
• Total number of polymer chains: 1
• Total formula weight: 32265.15

Authors

Vajdos, F.,Marr, E. (deposition date: 2008-01-17, release date: 2008-04-01, Last modification date: 2017-10-25)

• Primary citation: Roberts, W.G.,Ung, E.,Whalen, P.,Cooper, B.,Hulford, C.,Autry, C.,Richter, D.,Emerson, E.,Lin, J.,Kath, J.,Coleman, K.,Yao, L.,Martinez-Alsina, L.,Lorenzen, M.,Berliner, M.,Luzzio, M.,Patel, N.,Schmitt, E.,LaGreca, S.,Jani, J.,Wessel, M.,Marr, E.,Griffor, M.,Vajdos, F.; Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.; Cancer Res., 68:1935-1944, 2008; PubMed: 18339875; DOI: 10.1158/0008-5472.CAN-07-5155

Experimental method

X-RAY DIFFRACTION (2.2 Å)