3BWM
Crystal Structure of Human Catechol O-Methyltransferase with bound SAM and DNC
Summary for 3BWM
Entry DOI | 10.2210/pdb3bwm/pdb |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | comt, rossmann fold, sam, dnc, alternative initiation, catecholamine metabolism, cytoplasm, magnesium, membrane, methyltransferase, neurotransmitter degradation, polymorphism, s-adenosyl-l-methionine, transferase, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side: P21964 |
Total number of polymer chains | 1 |
Total formula weight | 24510.34 |
Authors | Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W. (deposition date: 2008-01-09, release date: 2008-06-03, Last modification date: 2023-08-30) |
Primary citation | Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W. Crystal structures of human 108V and 108M catechol O-methyltransferase. J.Mol.Biol., 380:120-130, 2008 Cited by PubMed: 18486144DOI: 10.1016/j.jmb.2008.04.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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