3BV3
Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2
Summary for 3BV3
Entry DOI | 10.2210/pdb3bv3/pdb |
Related | 3BV2 |
Descriptor | Mitogen-activated protein kinase 14, 5-methyl-4-[(2-methyl-5-{[(3-morpholin-4-ylphenyl)carbonyl]amino}phenyl)amino]-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, kinase, transferase, p38 map kinase, alternative splicing, atp-binding, cytoplasm, nucleotide-binding, nucleus, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42694.69 |
Authors | Sack, J.S. (deposition date: 2008-01-04, release date: 2008-04-15, Last modification date: 2024-02-21) |
Primary citation | Wrobleski, S.T.,Lin, S.,Hynes, J.,Wu, H.,Pitt, S.,Shen, D.R.,Zhang, R.,Gillooly, K.M.,Shuster, D.J.,McIntyre, K.W.,Doweyko, A.M.,Kish, K.F.,Tredup, J.A.,Duke, G.J.,Sack, J.S.,McKinnon, M.,Dodd, J.,Barrish, J.C.,Schieven, G.L.,Leftheris, K. Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 18:2739-2744, 2008 Cited by PubMed: 18364256DOI: 10.1016/j.bmcl.2008.02.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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