3BU5
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
Summary for 3BU5
Entry DOI | 10.2210/pdb3bu5/pdb |
Related | 3BU3 3BU6 |
Descriptor | insulin receptor subunit beta, Insulin receptor substrate 2, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | irk, krlb, irs2, atp, insulin receptor, substrate, alternative splicing, atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, transmembrane, tyrosine-protein kinase, transducer |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P06213 Cytoplasm, cytosol: P81122 |
Total number of polymer chains | 2 |
Total formula weight | 37280.92 |
Authors | Wu, J.,Hubbard, S.R. (deposition date: 2007-12-31, release date: 2008-02-19, Last modification date: 2021-10-20) |
Primary citation | Wu, J.,Tseng, Y.D.,Xu, C.F.,Neubert, T.A.,White, M.F.,Hubbard, S.R. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat.Struct.Mol.Biol., 15:251-258, 2008 Cited by PubMed: 18278056DOI: 10.1038/nsmb.1388 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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