3BGQ

Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2

Summary for 3BGQ

Entry DOI	10.2210/pdb3bgq/pdb
Related	3BGP 3BGZ
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine (3 entities in total)
Functional Keywords	kinase inhibitor phosphorylation, alternative initiation, atp-binding, cytoplasm, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	38345.44
Authors	Jacobs, M.D. (deposition date: 2007-11-27, release date: 2007-12-11, Last modification date: 2011-07-13)
Primary citation	Pierce, A.C.,Jacobs, M.,Stuver-Moody, C. Docking study yields four novel inhibitors of the protooncogene pim-1 kinase. J.Med.Chem., 51:1972-1975, 2008 Cited by PubMed: 18290603 DOI: 10.1021/jm701248t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation