3B7J

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone

Summary for 3B7J

Entry DOI	10.2210/pdb3b7j/pdb
Related	2GLL 2GLM 2GLP 2GLV
Descriptor	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... (5 entities in total)
Functional Keywords	fabz complex, juglone, cytoplasm, lipid a biosynthesis, lipid synthesis, lyase
Biological source	Helicobacter pylori (Campylobacter pylori)
Cellular location	Cytoplasm (By similarity): Q5G940
Total number of polymer chains	6
Total formula weight	110638.80
Authors	Zhang, L.,Kong, Y.H.,Wu, D.,Shen, X.,Jiang, H.L. (deposition date: 2007-10-31, release date: 2008-09-02, Last modification date: 2023-11-01)
Primary citation	Kong, Y.H.,Zhang, L.,Yang, Z.Y.,Han, C.,Hu, L.H.,Jiang, H.L.,Shen, X. Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization ACTA PHARMACOL.SIN., 29:870-876, 2008 Cited by PubMed: 18565285 DOI: 10.1111/j.1745-7254.2008.00808.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation