3AUQ
Crystal structure of the human vitamin D receptor ligand binding domain complexed with Yne-diene type analog of active 14-epi-2alpha-methyl-19-norvitamin D3
Summary for 3AUQ
Entry DOI | 10.2210/pdb3auq/pdb |
Descriptor | Vitamin D3 receptor, (1R,2S,3R)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethynyl]-2-methyl-cyclohex-4-ene-1,3-diol (3 entities in total) |
Functional Keywords | hormone receptor, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P11473 |
Total number of polymer chains | 1 |
Total formula weight | 30219.96 |
Authors | Kakuda, S.,Takimoto-Kamimura, M. (deposition date: 2011-02-15, release date: 2011-09-14, Last modification date: 2023-11-01) |
Primary citation | Sawada, D.,Tsukuda, Y.,Saito, H.,Kakuda, S.,Takimoto-Kamimura, M.,Ochiai, E.,Takenouchi, K.,Kittaka, A. Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor J.Am.Chem.Soc., 133:7215-7221, 2011 Cited by PubMed: 21500802DOI: 10.1021/ja201481j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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