3AQE

Crystal structure of the extracellular domain of human RAMP2

Summary for 3AQE

• Entry DOI: 10.2210/pdb3aqe/pdb
• Related: 3AQF
• Descriptor: Receptor activity-modifying protein 2 (2 entities in total)
• Functional Keywords: transmembrane, gpcr, adrenomedullin, trafficking, clr, cgrp, endoplasmic reticulum, disease, neovascularization, helix bundle, calcitonin receptor-like receptor (crlr), endoplasmic reticulum (er), cell membrane, transport protein
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: O60895
• Total number of polymer chains: 6
• Total formula weight: 63488.83

Authors

Kusano, S.,Kukimoto-Niino, M.,Shirouzu, M.,Shindo, T.,Yokoyama, S. (deposition date: 2010-10-29, release date: 2011-11-09, Last modification date: 2012-07-25)

• Primary citation: Kusano, S.,Kukimoto-Niino, M.,Hino, N.,Ohsawa, N.,Okuda, K.,Sakamoto, K.,Shirouzu, M.,Shindo, T.,Yokoyama, S.; Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding; Protein Sci., 21:199-210, 2012; PubMed: 22102369; DOI: 10.1002/pro.2003

Experimental method

X-RAY DIFFRACTION (2 Å)