3AOX

X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802

Summary for 3AOX

Entry DOI	10.2210/pdb3aox/pdb
Descriptor	ALK tyrosine kinase receptor, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	alk kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein: Q9UM73
Total number of polymer chains	1
Total formula weight	39545.49
Authors	Nagel, S.,Moertl, M.,Jestel, A.,Fukami, T.A. (deposition date: 2010-10-08, release date: 2011-05-25, Last modification date: 2023-11-01)
Primary citation	Sakamoto, H.,Tsukaguchi, T.,Hiroshima, S.,Kodama, T.,Kobayashi, T.,Fukami, T.A.,Oikawa, N.,Tsukuda, T.,Ishii, N.,Aoki, Y. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant Cancer Cell, 19:679-690, 2011 Cited by PubMed: 21575866 DOI: 10.1016/j.ccr.2011.04.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation