3AN4
Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R
Summary for 3AN4
Entry DOI | 10.2210/pdb3an4/pdb |
Related | 3AN3 |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid (3 entities in total) |
Functional Keywords | mainly alpha, nuclear receptor, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65627.05 |
Authors | Oyama, T.,Ohashi, M.,Waku, T.,Miyachi, H.,Morikawa, K. (deposition date: 2010-08-30, release date: 2011-07-27, Last modification date: 2023-11-01) |
Primary citation | Ohashi, M.,Oyama, T.,Nakagome, I.,Satoh, M.,Nishio, Y.,Nobusada, H.,Hirono, S.,Morikawa, K.,Hashimoto, Y.,Miyachi, H. Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship J.Med.Chem., 54:331-341, 2011 Cited by PubMed: 21128600DOI: 10.1021/jm101233f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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