3AI8

Cathepsin B in complex with the nitroxoline

Summary for 3AI8

• Entry DOI: 10.2210/pdb3ai8/pdb
• Descriptor: Cathepsin B, 5-nitroquinolin-8-ol (3 entities in total)
• Functional Keywords: cathepsin b, reversible inhibitor, nitroxoline, 8-hydroxy-5-nitroquinoline, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P07858
• Total number of polymer chains: 2
• Total formula weight: 56550.94

Authors

Renko, M.,Mirkovic, B.,Gobec, S.,Kos, J.,Turk, D. (deposition date: 2010-05-11, release date: 2011-05-18, Last modification date: 2023-11-01)

• Primary citation: Mirkovic, B.,Renko, M.,Turk, S.,Sosic, I.,Jevnikar, Z.,Obermajer, N.,Turk, D.,Gobec, S.,Kos, J.; Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds; Chemmedchem, 6:1351-1356, 2011; PubMed: 21598397; DOI: 10.1002/cmdc.201100098

Experimental method

X-RAY DIFFRACTION (2.11 Å)