3A4P
human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor
Summary for 3A4P
Entry DOI | 10.2210/pdb3a4p/pdb |
Related | 1r1w 2wgj |
Descriptor | Hepatocyte growth factor receptor, CHLORIDE ION, ISOPROPYL ALCOHOL, ... (5 entities in total) |
Functional Keywords | c-met, tyrosine-protein kinase, hepatocyte growth factor receptor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 36562.61 |
Authors | Fukami, T.A.,Kadono, S.,Yamamuro, M.,Matsuura, T. (deposition date: 2009-07-13, release date: 2010-02-16, Last modification date: 2023-11-01) |
Primary citation | Nishii, H.,Chiba, T.,Morikami, K.,Fukami, T.A.,Sakamoto, H.,Ko, K.,Koyano, H. Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors Bioorg.Med.Chem.Lett., 20:1405-1409, 2010 Cited by PubMed: 20093027DOI: 10.1016/j.bmcl.2009.12.109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
Download full validation report