3A29
Crystal structure of human liver FBPase in complex with tricyclic inhibitor
Summary for 3A29
| Entry DOI | 10.2210/pdb3a29/pdb |
| Descriptor | Fructose-1,6-bisphosphatase 1, 2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate (3 entities in total) |
| Functional Keywords | hydrolase, allosteric enzyme, carbohydrate metabolism, disease mutation, gluconeogenesis, magnesium, metal-binding, polymorphism |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 148105.93 |
| Authors | Takahashi, M.,Sone, J.,Hanzawa, H. (deposition date: 2009-05-08, release date: 2009-10-06, Last modification date: 2023-11-01) |
| Primary citation | Tsukada, T.,Takahashi, M.,Takemoto, T.,Kanno, O.,Yamane, T.,Kawamura, S.,Nishi, T. Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors Bioorg.Med.Chem.Lett., 19:5909-5912, 2009 Cited by PubMed: 19762234DOI: 10.1016/j.bmcl.2009.08.081 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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