2ZV2
Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609
Summary for 2ZV2
| Entry DOI | 10.2210/pdb2zv2/pdb |
| Descriptor | Calcium/calmodulin-dependent protein kinase kinase 2, 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (3 entities in total) |
| Functional Keywords | calcium/calmodulin-dependent protein kinase kinase 2, beta, sto-609, camkk2, e.c.2.7.11.17, phosphorylation, ampkk, metabolism, atp-binding, kinase, calmodulin-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus (By similarity): Q96RR4 |
| Total number of polymer chains | 1 |
| Total formula weight | 33921.95 |
| Authors | Yoshikawa, S.,Kukimoto-niino, M.,Shirouzu, M.,Suzuki, A.,Lee, S.,Minokoshi, Y.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2008-10-31, release date: 2009-11-03, Last modification date: 2023-11-01) |
| Primary citation | Kukimoto-Niino, M.,Yoshikawa, S.,Takagi, T.,Ohsawa, N.,Tomabechi, Y.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609 J.Biol.Chem., 286:22570-22579, 2011 Cited by PubMed: 21504895DOI: 10.1074/jbc.M111.251710 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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