2ZJO

Crystal structure of hepatitis C virus NS3 helicase with a novel inhibitor

Summary for 2ZJO

• Entry DOI: 10.2210/pdb2zjo/pdb
• Descriptor: Genome polyprotein, N-[4-(BIS{4-[(3-SULFOPHENYL)AMINO]PHENYL}METHYLENE)CYCLOHEXA-2,5-DIEN-1-YLIDENE]-4-SULFOBENZENAMINIUM (3 entities in total)
• Functional Keywords: protein-inhibitor complex, structure-based drug design, hydrolase
• Biological source: Hepatitis C virus (isolate Taiwan) (VIRUSES)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P29846
• Total number of polymer chains: 1
• Total formula weight: 52632.62

Authors

Liaw, S.H.,Chen, S.J.,Hu, C.Y.,Chi, W.K.,Chu, I.D.,Hwang, L.H.,Chern, J.W.,Chen, D.S. (deposition date: 2008-03-07, release date: 2009-03-10, Last modification date: 2023-11-01)

• Primary citation: Liaw, S.H.,Chen, S.J.,Hu, C.Y.,Chi, W.K.,Chu, I.D.,Hwang, L.H.,Chern, J.W.,Chen, D.S.; Structure-Based Discovery of Triphenylmethane Derivatives as Novel Inhibitors of Hepatitis C Virus Helicase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)