2ZEJ

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

Summary for 2ZEJ

Entry DOI	10.2210/pdb2zej/pdb
Descriptor	Leucine-rich repeat kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	parkinson's disease, lrrk2, roc, gtpase, roco, kinase, atp-binding, disease mutation, gtp-binding, gtpase activation, leucine-rich repeat, membrane, nucleotide-binding, parkinson disease, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	43778.48
Authors	Deng, J. (deposition date: 2007-12-13, release date: 2008-01-22, Last modification date: 2017-10-11)
Primary citation	Deng, J.,Lewis, P.A.,Greggio, E.,Sluch, E.,Beilina, A.,Cookson, M.R. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase Proc.Natl.Acad.Sci.Usa, 105:1499-1504, 2008 Cited by PubMed: 18230735 DOI: 10.1073/pnas.0709098105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation