2ZB2
Human liver glycogen phosphorylase a complexed with glcose and 5-chloro-N-[4-(1,2-dihydroxyethyl)phenyl]-1H-indole-2-carboxamide
Summary for 2ZB2
Entry DOI | 10.2210/pdb2zb2/pdb |
Descriptor | Glycogen phosphorylase, liver form, alpha-D-glucopyranose, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total) |
Functional Keywords | allosteric site, allosteric binding, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphorylation, pyridoxal phosphate, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 196984.15 |
Authors | Katayama, N.,Onda, K. (deposition date: 2007-10-15, release date: 2008-09-02, Last modification date: 2023-11-01) |
Primary citation | Onda, K.,Suzuki, T.,Shiraki, R.,Yonetoku, Y.,Negoro, K.,Momose, K.,Katayama, N.,Orita, M.,Yamaguchi, T.,Ohta, M.,Tsukamoto, S. Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a. Bioorg.Med.Chem., 16:5452-5464, 2008 Cited by PubMed: 18434170DOI: 10.1016/j.bmc.2008.04.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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