2YZA
Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)
Summary for 2YZA
Entry DOI | 10.2210/pdb2yza/pdb |
Related | 2H6D |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (2 entities in total) |
Functional Keywords | signaling protein, serine/threonine protein kinase, phosphorylation, atp-binding, nucleotide-binding, cholesterol biosynthesis, fatty acid biosynthesis, lipid synthesis, glucose metabolism, magnesium, metal-binding, serine/threonine-protein kinase, steroid biosynthesis, transferase, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): P54646 |
Total number of polymer chains | 1 |
Total formula weight | 31571.73 |
Authors | Saijo, S.,Takagi, T.,Yoshikawa, S.,Kishishita, S.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-05-04, release date: 2008-05-06, Last modification date: 2023-10-25) |
Primary citation | Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Takaya, D.,Toyama, M.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S. Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain Acta Crystallogr.,Sect.D, 67:480-487, 2011 Cited by PubMed: 21543851DOI: 10.1107/S0907444911010201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.02 Å) |
Structure validation
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