2XPC
Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid
Summary for 2XPC
Entry DOI | 10.2210/pdb2xpc/pdb |
Descriptor | UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, (1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | ligase, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase synthesis |
Biological source | ESCHERICHIA COLI |
Cellular location | Cytoplasm : Q8X9Y9 |
Total number of polymer chains | 1 |
Total formula weight | 48338.12 |
Authors | Sosic, I.,Barreteau, H.,Simcic, M.,Sink, R.,Cesar, J.,Golic-Grdadolnik, S.,Contreras-Martel, C.,Dessen, A.,Amoroso, A.,Joris, B.,Blanot, D.,Gobec, S. (deposition date: 2010-08-26, release date: 2011-05-18, Last modification date: 2023-12-20) |
Primary citation | Sosi, I.,Barreteau, H.,Sim, M.,Sink, R.,Cesar, J.,Zega, A.,Grdadolnik, S.G.,Contreras-Martel, C.,Dessen, A.,Amoroso, A.,Joris, B.,Blanot, D.,Gobec, S. Second-Generation Sulfonamide Inhibitors of D- Glutamic Acid-Adding Enzyme: Activity Optimisation with Conformationally Rigid Analogues of D- Glutamic Acid. Eur.J.Med.Chem, 46:2880-, 2011 Cited by PubMed: 21524830DOI: 10.1016/J.EJMECH.2011.04.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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