2XP2

Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)

Summary for 2XP2

• Entry DOI: 10.2210/pdb2xp2/pdb
• Descriptor: TYROSINE-PROTEIN KINASE RECEPTOR, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine (3 entities in total)
• Functional Keywords: crizotinib, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 37359.69

Authors

McTigue, M.,Deng, Y.,Liu, W.,Brooun, A.,Timofeevski, S.,Marrone, T.,Cui, J.J. (deposition date: 2010-08-24, release date: 2010-09-15, Last modification date: 2023-12-20)

• Primary citation: Cui, J.J.,Tran-Dube, M.,Shen, H.,Nambu, M.,Kung, P.P.,Pairish, M.,Jia, L.,Meng, J.,Funk, L.,Botrous, I.,Mctigue, M.,Grodsky, N.,Ryan, K.,Padrique, E.,Alton, G.,Timofeevski, S.,Yamazaki, S.,Li, Q.,Zou, H.,Christensen, J.,Mroczkowski, B.,Bender, S.,Kania, R.S.,Edwards, M.P.; Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk).; J.Med.Chem, 54:6342-, 2011; PubMed: 21812414; DOI: 10.1021/JM2007613

Experimental method

X-RAY DIFFRACTION (1.9 Å)