2WU6

Crystal Structure of the Human CLK3 in complex with DKI

Summary for 2WU6

• Entry DOI: 10.2210/pdb2wu6/pdb
• Related: 2EU9 2EXE 2WU7
• Descriptor: DUAL SPECIFICITY PROTEIN KINASE CLK3, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, SULFATE ION, ... (7 entities in total)
• Functional Keywords: transferase, kinase, tyrosine-protein kinase, serine/threonine-protein kinase, nucleotide-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49761
• Total number of polymer chains: 1
• Total formula weight: 46092.72

Authors

Muniz, J.R.C.,Fedorov, O.,King, O.,Filippakopoulos, P.,Bullock, A.N.,Philips, C.,Heightman, T.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S. (deposition date: 2009-09-30, release date: 2009-10-20, Last modification date: 2011-12-07)

• Primary citation: Fedorov, O.,Huber, K.,Eisenreich, A.,Filippakopoulos, P.,King, O.,Bullock, A.N.,Szklarczyk, D.,Jensen, L.J.,Fabbro, D.,Trappe, J.,Rauch, U.,Bracher, F.,Knapp, S.; Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.; Chem.Biol, 18:67-, 2011; PubMed: 21276940; DOI: 10.1016/J.CHEMBIOL.2010.11.009

Experimental method

X-RAY DIFFRACTION (1.92 Å)