2WGS
Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor.
Summary for 2WGS
Entry DOI | 10.2210/pdb2wgs/pdb |
Related | 1HTO 1HTQ 2BVC 2WHI |
Descriptor | GLUTAMINE SYNTHETASE 1, 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | relaxed state, purine analogue, nucleotide-binding, glna1, mt2278, ligase, rv2220, cytoplasm, synthetase |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 12 |
Total formula weight | 660533.57 |
Authors | Nilsson, M.T.,Krajewski, W.W.,Jones, T.A.,Mowbray, S.L. (deposition date: 2009-04-27, release date: 2009-09-01, Last modification date: 2023-12-13) |
Primary citation | Nilsson, M.T.,Krajewski, W.W.,Yellagunda, S.,Prabhumurthy, S.,Chamarahally, G.N.,Siddamadappa, C.,Srinivasa, B.R.,Yahiaoui, S.,Larhed, M.,Karlen, A.,Jones, T.A.,Mowbray, S.L. Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors. J.Mol.Biol., 393:504-, 2009 Cited by PubMed: 19695264DOI: 10.1016/J.JMB.2009.08.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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