2W9S
Staphylococcus aureus S1:DHFR in complex with trimethoprim
Summary for 2W9S
Entry DOI | 10.2210/pdb2w9s/pdb |
Related | 2W9T |
Descriptor | DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | antibiotic resistance, dhfr, nadp, oxidoreductase, trimethoprim resistance, one-carbon metabolism, methotrexate resistance |
Biological source | STAPHYLOCOCCUS AUREUS |
Total number of polymer chains | 6 |
Total formula weight | 115536.66 |
Authors | Soutter, H.H.,Miller, J.R. (deposition date: 2009-01-28, release date: 2009-03-24, Last modification date: 2024-05-08) |
Primary citation | Heaslet, H.,Harris, M.,Fahnoe, K.,Sarver, R.,Putz, H.,Chang, J.,Subramanian, C.,Barreiro, G.,Miller, J.R. Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim. Proteins, 76:706-, 2009 Cited by PubMed: 19280600DOI: 10.1002/PROT.22383 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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