2W2X

Complex of Rac2 and PLCg2 spPH Domain

Summary for 2W2X

Entry DOI	10.2210/pdb2w2x/pdb
Related	1DS6 2W2T 2W2V 2W2W
Descriptor	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2, 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (6 entities in total)
Functional Keywords	hydrolase, phospholipase c, phosphoinositides, rho gtpases, rac, sh2 domain, sh3 domain, signaling protein/hydrolase, signaling protein-hydrolase complex
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	70181.35
Authors	Opaleye, O.,Bunney, T.D.,Roe, S.M.,Pearl, L.H. (deposition date: 2008-11-04, release date: 2009-05-05, Last modification date: 2023-12-13)
Primary citation	Bunney, T.D.,Opaleye, O.,Roe, S.M.,Vatter, P.,Baxendale, R.W.,Walliser, C.,Everett, K.L.,Josephs, M.B.,Christow, C.,Rodrigues-Lima, F.,Gierschik, P.,Pearl, L.H.,Katan, M. Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34:223-, 2009 Cited by PubMed: 19394299 DOI: 10.1016/J.MOLCEL.2009.02.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation