2W0W

Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 2

Summary for 2W0W

• Entry DOI: 10.2210/pdb2w0w/pdb
• Related: 2V0H 2V0I 2V0J 2V0K 2V0L 2VD4 2W0V
• Descriptor: GLUCOSAMINE-1-PHOSPHATE N-ACETYLTRANSFERASE, N-{6-(CYCLOPROPYLMETHOXY)-7-METHOXY-2-[6-(2-METHYLPROPYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]QUINAZOLIN-4-YL}-2,2,2-TRIFLUOROETHANESULFONAMIDE, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: peptidoglycan synthesis, glmu, bacterial, inhibitor, magnesium, cell shape, transferase, active site, metal-binding, cell wall biogenesis/degradation, multifunctional enzyme, nucleotidyltransferase, acyltransferase, uridyltransferase
• Biological source: HAEMOPHILUS INFLUENZAE
• Cellular location: Cytoplasm (By similarity): P43889
• Total number of polymer chains: 1
• Total formula weight: 50135.92

Authors

Mochalkin, I.,Melnick, M. (deposition date: 2008-10-10, release date: 2009-11-17, Last modification date: 2023-12-13)

• Primary citation: Melnick, M.,Mochalkin, I.,Lightle, S.,Narasimhan, L.,Mcdowell, L.,Sarver, R.; Discovery and Initial Sar of Quinazoline Inhibitors of Glmu from Haemophilus Influenzae; To be Published,

Experimental method

X-RAY DIFFRACTION (2.59 Å)