2VUW
Structure of human haspin kinase domain
Summary for 2VUW
Entry DOI | 10.2210/pdb2vuw/pdb |
Descriptor | SERINE/THREONINE-PROTEIN KINASE HASPIN, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (7 entities in total) |
Functional Keywords | cell cycle, transferase, casp8, nucleotide binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q8TF76 |
Total number of polymer chains | 1 |
Total formula weight | 39389.05 |
Authors | Eswaran, J.,Murray, J.W.,Filippakopoulos, P.,Soundararajan, M.,Pike, A.C.W.,von Delft, F.,Picaud, S.,Keates, T.,King, O.,Wickstroem, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Fedorov, O.,Burgess-Brown, N.,Bray, J.,Knapp, S. (deposition date: 2008-05-30, release date: 2008-09-16, Last modification date: 2018-01-24) |
Primary citation | Eswaran, J.,Patnaik, D.,Filippakopoulos, P.,Wang, F.,Stein, R.L.,Murray, J.W.,Higgins, J.M.G.,Knapp, S. Structure and Functional Characterization of the Atypical Human Kinase Haspin. Proc.Natl.Acad.Sci.USA, 106:20198-, 2009 Cited by PubMed: 19918057DOI: 10.1073/PNAS.0901989106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report