2VQQ

Structure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor

Summary for 2VQQ

Entry DOI	10.2210/pdb2vqq/pdb
Related	2VQJ 2VQM 2VQO 2VQV 2VQW
Descriptor	HISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	inhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P56524
Total number of polymer chains	2
Total formula weight	90248.76
Authors	Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (deposition date: 2008-03-18, release date: 2008-07-08, Last modification date: 2023-12-13)
Primary citation	Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain. J.Biol.Chem., 283:26694-, 2008 Cited by PubMed: 18614528 DOI: 10.1074/JBC.M803514200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation