2VBQ

Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.

Summary for 2VBQ

Entry DOI	10.2210/pdb2vbq/pdb
Related	1S3Z 1S5K 1S60
Descriptor	AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE, (3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-3-hydroxy-2,2-dimethyl-4,8,15-trioxo-12-thia-5,9,16-triazaheptadec-9-en-1-yl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, NICKEL (II) ION, ... (5 entities in total)
Functional Keywords	aminoglycoside, acetyltransferase, drug resistance, bisubstrate inhibitor, transferase
Biological source	SALMONELLA CHOLERAESUIS
Total number of polymer chains	2
Total formula weight	39548.49
Authors	Vetting, M.W.,Magalhaes, M.L.,Freiburger, L.,Gao, F.,Auclair, K.,Blanchard, J.S. (deposition date: 2007-09-14, release date: 2008-01-08, Last modification date: 2024-05-08)
Primary citation	Magalhaes, M.L.,Vetting, M.W.,Gao, F.,Freiburger, L.,Auclair, K.,Blanchard, J.S. Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase. Biochemistry, 47:579-, 2008 Cited by PubMed: 18095712 DOI: 10.1021/BI701957C PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation