2V5A
CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 3
Summary for 2V5A
Entry DOI | 10.2210/pdb2v5a/pdb |
Related | 1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V59 2VR1 |
Descriptor | BIOTIN CARBOXYLASE, 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | fatty acid biosynthesis, biotin carboxylase, nucleotide-binding, atp-binding, antibacterial, lipid synthesis, fas, ligase, biotin, bacterial, inhibitor |
Biological source | ESCHERICHIA COLI |
Total number of polymer chains | 2 |
Total formula weight | 99133.55 |
Authors | Mochalkin, I.,Miller, J.R. (deposition date: 2008-10-02, release date: 2009-01-13, Last modification date: 2023-12-13) |
Primary citation | Miller, J.R.,Dunham, S.,Mochalkin, I.,Banotai, C.,Bowman, M.,Buist, S.,Dunkle, B.,Hanna, D.,Harwood, H.J.,Huband, M.D.,Karnovsky, A.,Kuhn, M.,Limberakis, C.,Liu, J.Y.,Mehrens, S.,Mueller, W.T.,Narasimhan, L.,Ogden, A.,Ohren, J.,Prasad, J.V.,Shelly, J.A.,Skerlos, L.,Sulavik, M.,Thomas, V.H.,Vanderroest, S.,Wang, L.,Wang, Z.,Whitton, A.,Zhu, T.,Stover, C.K. A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. Proc.Natl.Acad.Sci.USA, 106:1737-, 2009 Cited by PubMed: 19164768DOI: 10.1073/PNAS.0811275106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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